Software

This part of the history of PowerDNS is mostly about our business adventures & merger with Open-Xchange. The technical history of this period is described in part 3a. Business In 2013, PowerDNS was in a crucial phase. Existing business was going well, but we were receiving pointed signals there was trouble on the horizon. Some existing customers were close to deserting us, because we could not provide them with the top-down attention other vendors were lavishing on them.

Er is in Nederland een levendige discussie gaande of we in moeten zetten op kernenergie of niet. Afhankelijk van wie je spreekt is kernenergie een groene en noodzakelijke manier om onze CO₂-doelen te halen, of is het overbodige onzin. Ik ben een groot gelover in het idee van kernenergie. Maar onze auto’s en huizen kunnen we niet aandrijven met ideeën. Die drijf je aan met kerncentrales. En daar hebben we het nooit over, de kernindustrie.

Brief post, in response to the many many many technical people that propose to print their own mRNA vaccines “now that the source is out there”. I’ve spent a lot of time individually explaining why this is unlikely to happen any time soon, and I thought it a good idea to explain it here as well. Mountains of details on how the vaccines are actually produced can be found on this awesome page by Jonas Neubert and Cornelia Scheitz.

UPDATE: Back in December 2020 when this article was first posted, I noted that some receivers might not be able to deal with the advent of production signals from the eccentric satellites. This has indeed proved to be a problem for U-blox F9 series receivers in a specific configuration. The application note links to this article (thanks!) and also (correctly) states that the signals from the eccentric satellites do not in fact comply with the Galileo Open Service ICD.

En toen was het toch weer tijd voor een Corona Update, de eerste sinds november 2020. Doordat er zoveel nieuws is geweest over varianten en vaccins is het zicht een beetje kwijt op waar we nu zijn. En dat is des te vervelender nu de cijfers weer omhoog lijken te gaan. Daarom een samenvatting die eigenlijk heel rooskleurig is, zelfs met de varianten. Dit betekent overigens niet dat de maatregelen al opgeheven kunnen worden!

In short, if you need engaging in-depth articles on your scientific project, your research breakthrough or the grand new technical/space/molecular/medical thing you are building, you can hire me! (Semi-)Popular science writing I do a lot of what I call “(Semi-)popular science writing”. My recent article dissecting the BioNTech/Pfizer SARS-CoV-2 vaccine has racked up over 1.5 million views (so far), and it has done the rounds of the pharmaceutical world where it got favourable reviews.

In previous posts I described how the two currently approved mRNA vaccines both use ‘modified nucleosides’ to enhance their efficiency. Meanwhile, a company called CureVac has created an mRNA vaccine that uses regular, unmodified, RNA. It is currently being tested in large scale trials. In this post I explain what the challenges are with this plain RNA approach, and we reverse engineer quite closely what CureVac has done with regular RNA to (hopefully) deliver an effective vaccine.

This article is part of a series on (European) innovation and capabilities. Periodically I read about governments or institutions wanting to stimulate innovation, often to achieve a certain (worthy) goal. Frequently, the far larger amounts of money that other countries or continents are spending on innovation are then bandied about as justification. And I die a little inside every time that happens. Money and innovation have a very intricate relation.

There are lots of calls to invest in improving cybersecurity. But it struck me that it doesn’t work like that. Not getting hacked is not so much a question of buying the right stuff. It is a question of doing the right things and understanding what you are doing. It is easy to demand that people ‘invest’ in something. You can even supply them with the money to do so.

Hi everyone, With apologies for flooding the airwaves and timelines with way too many posts and tweets, here’s one more post, the last COVID-19 related one for a while. I’ve been trying to provide high quality answers to the many questions I receive via email and various social media. I’ve also been trying to help many many people that found worrying news online & sent it to me, either for reassurance or simply to challenge me.

This article is part of a series on (European) innovation and capabilities. Hi everyone, This is a transcript of my presentation over at the European Microwave Week 2020, actually held in 2021. You can find the video here and the slides here. I’d like to thank Frank van Vliet, general chair of the EMW, for inviting me to do this talk. The words have only been edited lightly - it is still presentation style, so here and there the sentences are not written like how they’d be in a more formal piece of work.

Translations: 中文, 日本語 As a followup to Reverse Engineering the source code of the BioNTech/Pfizer SARS-CoV-2 Vaccine, here is a look at the genetic code behind some of the other vaccines. I recommend at least skimming the earlier post before delving into this one, unless you are already fluent in modified mRNA bases and protein expression mechanics. To get an extremely full background on all vaccine work, I kindly refer you to excellent posts from Derek Lowe and Hilda Bastian.

Translations: ελληνικά / عربى / 中文 (Weixin video, Youtube video) / 粵文 / bahasa Indonesia / český / Català / český / Deutsch / Español / 2فارسی / فارسی / Français / עִברִית / Hrvatski / Italiano / Nederlands / 日本語 / 日本語 2 / नेपाली / Polskie / русский / Português / Română / Slovensky / Slovenščina / Türk / український / Markdown for translating Dobro došli! U ovom postu ćemo, znak po znak, ispitati izvorni kôd vakcine mRNA BioNTech / Pfizer SARS-CoV-2.

Updates: 12th of September 2021: I’m writing a book on DNA! If you want to become a beta reader, or have suggestions, I’d love to hear from you! 8th of January 2021: This article has been revised and updated, scientifically and in terms of dead links. Revision made by Tomás Simões (@putadagravidade / tomasprsimoes@gmail.com). Feel free to contact me if I made a mistake. 25th of August 2017: This page has led to a two-hour presentation called DNA: The code of Life as presented at SHA 2017.

Translations: ελληνικά / عربى / 中文 (Weixin video, Youtube video) / 粵文 / bahasa Indonesia / český / Català / český / Deutsch / English / Español / 2فارسی / فارسی / Français / עִברִית / Hrvatski / Italiano / Nederlands / 日本語 / 日本語 2 / नेपाली / Polskie / русский / Português / Română / Slovensky / Türk / український / Markdown for translating Pozdravljeni! V tem članku bomo črko po črko pregledali izvorno kodo cepiva BioNTech/Pfizer SARS-CoV-2 mRNA.

UPDATE: Deze post was ooit geschreven voor de toenmalige Corona(vaccin) situatie. Maar, hij is inzetbaar voor ieder ontspoord of ontsporend familielid of contact. De grote lijn blijft hetzelfde - iemand roept allemaal rare dingen en beïnvloedt zo de rest. Onderstaand verhaal gaat over hoe je dit nuttig om kan draaien. We hebben Coronamaatregelen, en men houdt zich er niet aan. Er zijn prachtige Coronavaccins, en mensen melden luidruchtig deze nooit te gaan nemen.

In this page I want to offer some guidance how you can be useful in spreading good Corona information, specifically about vaccines. Importantly, many readers of my blog are the technology help desk for their families - the people that help fixing the wifi, install new computers and generally are useful for solving complex problems. That makes you, the reader very imporant. Your family and friends see you as someone who knows what they are talking about.

NOT Bu yazı, https://berthub.eu/articles/posts/reverse-engineering-source-code-of-the-biontech-pfizer-vaccine/ adresindeki yazının Türkçe çevirisidir. https://gist.github.com/ugurkoltuk/2f87d8038d4fd42f4c6ad13472966797 Hoşgeldiniz! Bu yazıda, BioNTech/Pfizer SARS-CoV-2 mRNA aşısının kaynak kodunu karakter karakter inceleyeceğiz. Bu yazıyı anlaşılırlık ve doğruluk açısından gözden geçiren pek çok insana teşekkür ederim. Tüm hatalar yine de benim hatalarımdır ve hataları hızla bert@hubertnet.nl ya da @bert_hu_bert adreslerinden birine bildirmenizi rica ederim (Çevirmenin notu: çeviri ya da Türkçe dil hatalarını da aşağıdaki yorum bölümünü kullanarak bildirmenizi rica ederim.) Kulağa yanlış geliyor olabilir - sonuçta aşı, kolunuzdan damarınıza enjekte edilen bir sıvı.

All BNT162b2 vaccine data on this page is sourced from this World Health Organization document. This is a living page, shared already so people can get going! But check back frequently for updates. Translation: Français / 日本語 In short: the vaccine mRNA has been optimized by the manufacturer by changing bits of RNA from (say) UUU to UUC, and people would like to understand the logic behind these changes. This challenge is quite close to what cryptologists and reverse engineering people encounter regularly.